TABLE 3.
Association of dietary and total magnesium intakes at diagnosis with recurrence and all-cause mortality in CRC patients1
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | P-trend | |
|---|---|---|---|---|---|
| Dietary magnesium intake | |||||
| CRC recurrence | |||||
| n/Events | 280/34 | 281/36 | 280/35 | 280/40 | |
| Events/1000 person-years | 35 | 35 | 35 | 43 | |
| Model 1 | |||||
| HR (95% CI) | 1.0 (ref) | 1.02 (0.64, 1.63) | 1.01 (0.63, 1.61) | 1.20 (0.76, 1.89) | 0.47 |
| Model 2 | |||||
| HR (95% CI) | 1.0 (ref) | 1.19 (0.72, 1.97) | 1.10 (0.61, 2.01) | 1.38 (0.66, 2.87) | 0.70 |
| Model 3 | |||||
| HR (95% CI) | 1.0 (ref) | 1.25 (0.74, 2.08) | 1.20 (0.64, 2.26) | 1.56 (0.71, 3.46) | 0.40 |
| All-cause mortality | |||||
| n/Events | 280/56 | 282/42 | 282/34 | 281/42 | |
| Events/1000 person-years | 41 | 29 | 24 | 31 | |
| Model 1 | |||||
| HR (95% CI) | 1.0 (ref) | 0.71 (0.48, 1.06) | 0.59 (0.38, 0.90) | 0.76 (0.51, 1.13) | 0.10 |
| Model 2 | |||||
| HR (95% CI) | 1.0 (ref) | 0.65 (0.42, 1.00) | 0.46 (0.26, 0.79) | 0.51 (0.26, 0.98) | 0.04 |
| Model 3 | |||||
| HR (95% CI) | 1.0 (ref) | 0.69 (0.44, 1.09) | 0.52 (0.29, 0.93) | 0.59 (0.29, 1.20) | 0.15 |
| Total magnesium intake (diet and supplements) | |||||
| CRC recurrence | |||||
| n/Events | 280/34 | 281/34 | 280/37 | 280/40 | |
| Events/1000 person-years | 35 | 33 | 38 | 42 | |
| Model 1 | |||||
| HR (95% CI) | 1.0 (ref) | 0.96 (0.60, 1.55) | 1.07 (0.67, 1.70) | 1.18 (0.75, 1.86) | 0.42 |
| Model 2 | |||||
| HR (95% CI) | 1.0 (ref) | 1.15 (0.69, 1.90) | 1.20 (0.69, 2.11) | 1.39 (0.77, 2.53) | 0.24 |
| Model 3 | |||||
| HR (95% CI) | 1.0 (ref) | 1.19 (0.72, 1.99) | 1.32 (0.74, 2.36) | 1.57 (0.84, 2.92) | 0.13 |
| All-cause mortality | |||||
| n/Events | 280/55 | 282/46 | 282/36 | 281/37 | |
| Events/1000 person-years | 41 | 33 | 26 | 27 | |
| Model 1 | |||||
| HR (95% CI) | 1.0 (ref) | 0.80 (0.54, 1.18) | 0.63 (0.41, 0.95) | 0.66 (0.40, 1.00) | 0.02 |
| Model 2 | |||||
| HR (95% CI) | 1.0 (ref) | 0.77 (0.50, 1.19) | 0.48 (0.29, 0.82) | 0.55 (0.31, 0.98) | 0.02 |
| Model 3 | |||||
| HR (95% CI) | 1.0 (ref) | 0.83 (0.53, 1.28) | 0.55 (0.32, 0.95) | 0.65 (0.35, 1.21) | 0.11 |
Quartiles of intake were cohort-specific. Dietary intake of magnesium: COLON quartile 1: <246 mg/d; quartile 2: 246–305 mg/d; quartile 3: 306–371 mg/d; quartile 4: >371 mg/d; EnCoRe quartile 1: <300 mg/d; quartile 2: 300–364 mg/d; quartile 3: 364–429 mg/d; quartile 4: >429 mg/d. Total intake of magnesium: COLON quartile 1: <258 mg/d; quartile 2: 258–322 mg/d; quartile 3: 323–398 mg/d; quartile 4: >398 mg/d; EnCoRe quartile 1: <315 mg/d; quartile 2: 315–383 mg/d; quartile 3: 384–463 mg/d; quartile 4: >464 mg/d. Model 1: crude Cox proportional hazard model. Model 2: adjusted for age, sex, stage, BMI, physical activity (moderate to vigorous; h/wk), tumor location, cohort, and total energy intake. Model 3: as model 2 and further adjusted for dietary calcium and vitamin D concentrations for the dietary intake models and total calcium and vitamin D concentrations for the total intake (diet and supplements) models. P values for trend were calculated by including the quartiles as a continuous variable in the model. COLON, COlorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life; CRC, colorectal cancer; EnCoRe, Energy for life after ColoRectal cancer.