TABLE 2.
Baseline values of iron and inflammatory markers by study group and treatment arm1
| CM | Severe malarial anemia | Community children | ||||
|---|---|---|---|---|---|---|
| Immediate | Delayed | Immediate | Delayed | Immediate | Delayed | |
| n | 39 | 40 | 39 | 38 | 19 | 16 |
| Hemoglobin, g/dL | 7.0 ± 1.9 | 7.0 ± 1.9 | 3.6 ± 0.87 | 3.9 ± 1.0 | 11.0 ± 1.5 | 11.4 ± 1.2 |
| ZPP, μmol/mol heme | 261 (225, 303) | 263 (219, 316) | 396 (324, 484) | 357 (286, 445) | 134 (111, 163) | 117 (98, 139) |
| Ferritin, μg/L | 984 (754, 1284)2 | 1162 (798, 1691) | 912 (644, 1291) | 717 (487, 1054) | 45.0 (28.2, 71.9) | 30.5 (14.7, 63.0) |
| sTfR, mg/L | 3.7 (3.3, 4.3)2 | 4.4 (3.9, 4.9) | 6.6 (5.6, 7.9) | 7.5 (6.3, 8.9) | 6.5 (5.3, 7.3) | 5.5 (4.4, 6.8) |
| Hepcidin, ng/mL | 135 (97.1, 188) | 145 (109, 193) | 47.6 (29.2, 77.6) | 67.8 (44.7, 103) | 21.9 (13.1, 36.7) | 18.3 (11.5, 28.9) |
| CRP, mg/L | 686 (582, 807)2 | 816 (647, 1028) | 474 (368, 610) | 532 (414, 684) | 5.6 (2.0, 15.6) | 2.1 (0.38, 11.6) |
1
Values are means ± SDs or geometric means (95% CIs) unless otherwise indicated. CM, cerebral malaria; CRP, C-reactive protein; sTfR, soluble transferrin receptor; ZPP, zinc protoporphyrin.
2
n = 38 for CM immediate group.