TABLE 4.

Adjusted mean values of iron and inflammatory markers over 12 mo follow-up in each study group, according to immediate and delayed iron treatment¹

	Cerebral malaria				Severe malarial anemia				Community children
	Immediate	Delayed	Mean effect2	P	Immediate	Delayed	Mean effect	P	Immediate	Delayed	Mean effect	P
Hemoglobin,3 g/dL	12.4 ± 0.2	12.1 ± 0.2	0.33 (−0.2, 0.8)	0.20	11.3 ± 0.3	11.7 ± 0.3	−0.4 (−1.1, 0.3)	0.28	12.2 ± 0.2	11.9 ± 0.2	0.34 (−0.2, 0.9)	0.20
ZPP,4 μmol/mol heme	71 ± 1.0	73 ± 1.1	0.98 (0.9, 1.1)	0.72	108 ± 1.1	82 ± 1.1	1.3 (1.1, 1.6)	0.01	90 ± 1.1	76 ± 1.1	1.2 (0.9, 1.5)	0.16
Ferritin,4 μg/L	70.2 ± 1.1	81.5 ± 1.1	0.86 (0.63, 1.2)	0.36	127 ± 1.2	108 ± 1.2	1.2 (0.8, 1.8)	0.47	51.2 ± 1.2	50.9 ± 1.2	1.0 (0.6, 1.7)	0.99
sTfR,4 mg/L	5.6 ± 1.1	5.6 ± 1.1	0.99 (0.84, 1.2)	0.91	7.8 ± 1.1	6.1 ± 1.1	1.3 (1.0, 1.6)	0.03	6.4 ± 1.1	5.7 ± 1.1	1.1 (0.9, 1.4)	0.24
Hepcidin,4 ng/mL	23.9 ± 1.1	27.8 ± 1.1	0.86 (0.6, 1.2)	0.40	25.5 ± 1.2	34.1 ± 1.2	0.75 (0.5, 1.2)	0.19	15.6 ± 1.2	30.9 ± 1.3	0.50 (0.3, 1.0)	0.04
CRP,4 mg/L	12.1 ± 1.4	16.3 ± 1.4	0.74 (0.3, 1.7)	0.49	42.1 ± 1.3	25.5 ± 1.3	1.7 (0.7, 3.7)	0.21	12.9 ± 1.4	29.5 ± 1.5	0.44 (0.1, 1.3)	0.14

¹The value of each indicator at 6 and 12 mo was averaged and then modeled as the dependent variable in multiple linear regression equations performed separately by study group, which adjusted for treatment arm (immediate or delayed) and the baseline value of the indicator. The averaged value of all variables other than hemoglobin was log transformed before analysis. CRP, C-reactive protein; sTfR, soluble transferrin receptor; ZPP, zinc protoporphyrin.

²Immediate minus delayed for hemoglobin (95% CI); ratio of immediate-to-delayed (95% CI) for all other indicators.

³Values are arithmetic means ± SEs.

⁴Values are geometric means ± SEs.