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Contribution of REDD1 to the resuppression of mTORC1 activity during prolonged leucine deprivation. (A) Representative blots. (B–E) Quantitation of Western blots. Values are means ± SEM, n = 3. Panels B, C, and E: 2-way ANOVA. Panel D: 1-way ANOVA. Labeled means without a common letter differ, P < 0.05. ATF4, activating transcription factor 4; mTOR, mechanistic target of rapamycin; mTORC, mTOR complex; REDD1, regulated in development and DNA damage responses 1.
