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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Gastroenterology. 2020 Feb 4;158(6):1667–1681.e12. doi: 10.1053/j.gastro.2020.01.045

Figure 5. TIMP-GLIA tolerance induction reverses gliadin memory T cell enteropathy in mice.

Figure 5.

A) Experimental design. B) Total body weight development in four groups of Rag1−/− mice, treated according to A (n=14–16; data expressed as percentage of starting weight). C) Histological duodenitis severity scores (n=14–16; max. score 9). D-G) Hematoxylin/eosin staining of duodenal sections. Examples represent histological scores of D) 0 (normal), E) 3 (mild), F) 6 (moderate), or G) 9 (severe) duodenitis. Note increased villus and basal mononuclear cell infiltration, reduced villus-to-crypt ratios, and development of crypt abscesses with increasing scores. H-K). IFNG, IL17, IL2 and IL10 cytokine secretion in response to gliadin, or ovalbumin (Ova, negative control), in relation to anti-CD3/anti-CD28 antibody (positive control; n=9–12; ELISA; data expressed as cytokine secretion ratios). Statistical analyses were performed using one-way ANOVA and Tukey’s multiple comparison test (*p≤0.05, **p≤0.01, ***p≤0.001).