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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Acta Biomater. 2020 Mar 7;108:111–127. doi: 10.1016/j.actbio.2020.03.007

Figure 8.

Figure 8.

In vivo hESC-derived ONP spheroid transplantation in the DTR mouse cochlea. (A): A schematic diagram of experimental design for in vivo hESC-derived ONP spheroid transplantation. (B): Tone-burst-evoked ABR assessment of a WT mouse. (C): Tone-burst-evoked ABR assessment of a DTR mouse. (D): Click-evoked ABR assessment of WT mouse (left column) and DTR mouse (right column). (E): ABR audiograms for 3 DTR and 8 WT mouse ears, with mean values for the latter shown with the gray line. Levels are expressed in terms of attenuation, with sound pressure levels at 0 dB ranging from 105 to 120 dB SPL. Thresholds were based upon visual detection of a response above the noise floor. No ABRs were detected for the three DTR mice (data plotted above the 0 dB line).