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18F-FAC PET can monitor immunomodulatory drug treatments in an EAE mouse model. Hematoxylin and eosin stains of brain sections (A) and sagittal PET/CT images and quantification of 18F-FAC accumulation (B) in brains of mice before and after immunization and treated with vehicle or fingolimod. Hematoxylin and eosin images are at ×40 magnification, with ×1 shown in insets. Brains are outlined in white. Scale bar = 50 μm. **P < 0.01. ***P < 0.001.
