Table 1.

Attribute and Level Grid

	Attributes	Level 1	Level 2	Level 3	Level 4	Level 5
1	Storage	Refrigerator (must be stored in the refrigerator)	Refrigerator (must be stored in the refrigerator)	Refrigerator (must be stored in the refrigerator)	Room Temp (store at room temperature)	Room Temp (store at room temperature)
1b	Preparation	Mix (mix the medicine before use)	Ready to Use (no mixing required)	Mix, Then Room Temp (mix the medicine before use; once mixed can be stored at room temperature)	Mix (mix the medicine before use)	Ready to Use (no mixing required)
2	Injection device	Injection Device (continuous push on the button/plunger while injecting)	Autoinjector (single push of the button to inject)	Needle Free Device (pushes medicine through the skin using high pressure)
3	Maintenance	Single Use, Disposable Syringe (throw away after one use)	Multi Use, Disposable Pen (use for up to 28 days, then throw away)	Multi Use, Disposable Pen (use for up to 28 days, then throw away)	Multi Use, Reusable Pen (use for up to 28 days, then replace cartridge)	Multi Use, Reusable Pen (use for up to 28 days, then replace cartridge)
3b	Dose setting	Pre-Set Dose (dose is already pre-set)	Set the Dose (must set the dose each time)	Dose Memory (set the dose the first time, then device remembers it)	Set the Dose (must set the dose each time)	Dose Memory (set the dose the first time, then device remembers it)
4	Injection schedule	Once Daily	Once Weekly	Once Every 2 Weeks	Once a Month