Table 1.
Most frequent HLA-A~B~DRB1 phased haplotypes and linkage disequilibrium among allele pairs in the cohort of 291 patients
| Haplotype | Freq. | Count | LD A-B | LD A-DRB1 | LD B-DRB1 | Rank SBSC | Rank NMDP EUR | Rank NMDP AFA | Rank NMDP API | Rank NMDP HIS |
|---|---|---|---|---|---|---|---|---|---|---|
| A*01:01~B*08:01~DRB1*03:01 | 0.0326 | 19 | 8.38 | 4.08 | 11.67 | 1 | 1 | 2 | 40 | 2 |
| A*03:01~B*07:02~DRB1*15:01 | 0.0206 | 12 | 3.93 | 2.11 | 9.71 | 2 | 2 | 7 | NA | 3 |
| A*02:01~B*07:02~DRB1*15:01 | 0.0172 | 10 | 0.31 | 0.73 | 9.71 | 5 | 4 | 41 | 615 | 9 |
| A*03:01~B*35:01~DRB1*01:01 | 0.0137 | 8 | 4.31 | 2.96 | 8.38 | 4 | 8 | 149 | 75 | 23 |
| A*29:02~B*44:03~DRB1*07:01 | 0.012 | 7 | 11.31 | 3.50 | 9.25 | 6 | 5 | 9 | 1257 | 1 |
| A*01:01~B*57:01~DRB1*07:01 | 0.012 | 7 | 6.78 | 0.36 | 5.85 | 8 | 7 | 58 | 8 | 22 |
| A*26:01~B*38:01~DRB1*13:01 | 0.0103 | 6 | 9.71 | 2.26 | 4.56 | 42 | 53 | NA | NA | 162 |
| A*02:01~B*44:02~DRB1*04:01 | 0.0086 | 5 | 3.37 | 2.53 | 4.24 | 3 | 3 | 10 | 1292 | 46 |
| A*30:01~B*13:02~DRB1*07:01 | 0.0086 | 5 | 11.98 | 3.98 | 7.17 | 10 | 10 | 178 | 4 | 16 |
| A*24:02~B*07:02~DRB1*15:01 | 0.0086 | 5 | 1.14 | 0.67 | 9.71 | 13 | 13 | 337 | 183 | 72 |
| A*02:01~B*51:01~DRB1*11:01 | 0.0086 | 5 | 2.38 | 0.08 | 3.47 | 15 | 28 | 122 | 496 | 27 |
| A*01:01~B*08:01~DRB1*15:01 | 0.0086 | 5 | 8.38 | −0.23 | −0.17 | 25 | 25 | 544 | NA | NA |
| A*24:02~B*08:01~DRB1*03:01 | 0.0086 | 5 | 0.34 | 0.63 | 11.67 | 47 | 34 | 1379 | 268 | 42 |
| A*02:01~B*15:01~DRB1*04:01 | 0.0069 | 4 | 2.22 | 2.53 | 7.06 | 9 | 6 | 21 | 1419 | 39 |
| A*02:01~B*18:01~DRB1*03:01 | 0.0069 | 4 | 0.22 | 0.17 | 2.82 | 68 | 71 | 80 | NA | 40 |
| A*02:01~B*40:01~DRB1*13:02 | 0.0052 | 3 | 1.11 | −0.35 | 3.16 | 7 | 9 | 81 | NA | 554 |
| A*02:01~B*08:01~DRB1*03:01 | 0.0052 | 3 | −1.86 | 0.17 | 11.67 | 17 | 11 | 20 | NA | 18 |
| A*02:01~B*18:01~DRB1*11:04 | 0.0052 | 3 | 0.22 | 0.08 | 5.69 | 24 | 33 | NA | NA | 70 |
| A*31:01~B*40:01~DRB1*04:04 | 0.0052 | 3 | 5.40 | 4.09 | 6.07 | 27 | 20 | 98 | 1264 | 137 |
| A*02:01~B*51:01~DRB1*08:01 | 0.0052 | 3 | 2.38 | 0.55 | 1.78 | 29 | 73 | 245 | NA | 203 |
| A*32:01~B*44:03~DRB1*07:01 | 0.0052 | 3 | 2.06 | 1.81 | 9.25 | 120 | 291 | NA | 236 | 234 |
| A*01:01~B*15:17~DRB1*13:02 | 0.0052 | 3 | 4.04 | 2.70 | 8.41 | 210 | 327 | NA | 55 | 284 |
| A*02:01~B*13:02~DRB1*13:01 | 0.0052 | 3 | −0.04 | 0.09 | 1.15 | 333 | NA | 1131 | NA | NA |
LD: pairwise linkage disequilibrium as defined by standardized residuals; values ≥2 correspond to a significant association. Haplotypes in complete linkage (i.e. across the three loci) are shown in bold.
Rank of haplotypes estimated in 6114 volunteer donors from the Swiss registry (SBSC) and in four large groups (EUR: donors of European descent, AFA: donors of African descent, API: donors of Asian descent, HIS: donors of South American descent) of volunteer donors from the National Marrow Donor Program (NMDP) (ref. 34)
NA not available