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. 2020 May 4;10:7449. doi: 10.1038/s41598-020-64440-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Safety assessment of FUS-LBx. (A) Calculated cavitation levels for each of the 7 pigs found no significant increase of IC after microbubble injection (post-MB) compared with before microbubble injection (pre-MB). (B) T₂^*-weighted images show no sign of hemorrhage after FUS treatment. (C) The 3D-printed brain slicing matrix was used to cut the brain into 3-mm thick slabs around the FUS treatment area. The gross pathological examinations did not find visible signs of tissue damage. The dark spots visible in the upper-right area of the whole brain slices were from uneven slicing where the lateral ventricle (black) was becoming visible on the right hemisphere but not visible on the left hemisphere. (D) H&E staining of the whole brain slices with microscopic views at FUS + and FUS- sites did not suggest cellular damage.