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. 2020 May 4;10:126. doi: 10.1038/s41398-020-0809-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Reduced cortical thickness of AN patients compared to HC at the beginning of treatment (TP1). Significant clusters (blue, p < 0.05), corrected for multiple comparisons using Monte-Carlo simulations (5000 permutations). b Increase of cortical thickness during weight restoration in AN patients. Significant interaction of group × time (red, p < 0.05; yellow, p < 0.01), controlled for multiple comparisons with FDR correction. c Residual cortical thinning in AN patients compared to HC at the end of treatment (TP3). A significant cluster (blue, p < 0.05) remained in the superior frontal region (AN: mean = 2.71 mm ± 0.15, HC: mean = 2.86 mm ± 0.19), after correcting for multiple comparisons using Monte-Carlo simulation (5000 permutations). A anterior, L left, R right.