Table 2.

Comparison of cortical and subcortical brain volumes per group and time point (cm³).

	Group and time point										AN1 vs. AN2	AN2 vs. AN3	HC1 vs. HC3	AN1 vs. HC1	AN3 vs. HC3
	AN1 (n = 24)		AN2 (n = 26)		AN3 (n = 26)		HC1 (n = 30)		HC3 (n = 30)
	M	SD	M	SD	M	SD	M	SD	M	SD	g	g	g	g	g
Gray matter, cortex	448.57	27.22	468.49	32.88	476.62	34.85	473.37	38.23	471.80	35.23	0.66***	0.24***	−0.04	0.73*	−0.14
Gray matter, subc.	57.38	3.79	58.46	3.80	58.90	3.98	59.99	4.03	59.85	3.98	0.28***	0.11**	−0.03	0.66°	0.24
White matter	438.10	35.55	440.29	36.59	442.73	37.17	450.82	51.94	447.36	50.06	0.06	0.07	−0.07	0.28	0.10
Cortico-spinal fluid	23.97	10.01	21.58	8.81	20.77	8.89	15.61	4.08	15.64	4.11	−0.25***	−0.09**	0.01	−1.14**	−0.76°
Intracranial volume	1549.12	123.27	1557.25	137.46	1557.25	137.46	1523.39	159.25	1523.39	159.25	0.06	0.00	0.00	−0.18	−0.23
Accumbens nucleus	0.40	0.08	0.40	0.08	0.41	0.08	0.45	0.09	0.45	0.08	−0.08	0.06	−0.02	0.56	0.62
Amygdala	1.57	0.15	1.61	0.14	1.61	0.15	1.63	0.13	1.62	0.13	0.17**	0.02	−0.03	0.49	0.28
Caudate nucleus	3.59	0.42	3.73	0.43	3.75	0.46	3.80	0.42	3.76	0.41	0.26*	0.04	−0.08	0.57	0.23
Hippocampus	4.12	0.38	4.21	0.36	4.26	0.37	4.40	0.34	4.42	0.37	0.19***	0.13**	0.03	0.92*	0.66
Pallidum	1.97	0.14	1.97	0.14	1.97	0.12	2.02	0.23	2.04	0.23	−0.07	−0.01	0.11	0.38	0.58
Putamen	4.93	0.49	4.99	0.46	4.98	0.50	5.10	0.53	5.07	0.53	0.06	−0.01	−0.05	0.46	0.38
Thalamus	7.36	0.45	7.59	0.53	7.70	0.55	7.81	0.64	7.79	0.62	0.24***	0.14***	−0.04	0.83*	0.34

Mean values represent absolute values. Individual subcortical volumes were averaged across hemispheres and comparisons were performed with mean values corrected for total intracranial volume.

g Hedges’ g, subc. subcortical.

°p < 0.10, *p < 0.05, **p < 0.01, ***p < 0.001 adjusted for multiple comparisons according to Holm−Bonferroni.