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. 2020 May 4;11(5):308. doi: 10.1038/s41419-020-2502-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — C2C12 cells were transfected with siRNAs and differentiation induced. After 3 days in differentiation medium the effect on cell fusion was assessed. a Immunofluorescence showing the effect of specific siRNAs on cell fusion compared with that of a scrambled siRNA. b Knockdown of caspase-2 and Bid assessed by immunoblotting. c Quantitation of the effect of siRNAs on cell fusion. d tBid levels during differentiation assessed by immunoblotting and quantified (e). Data are the mean ± SD of three independent experiments (*P < 0.05). Scale bars represent 50 µm.