Fig. 2. Tumour mutation burden in TGCT.

Box plot showing that tumour mutation burden (TMB) is higher in platinum-resistant tumours vs. platinum-sensitive/unselected tumours (a, b) and metastatic tumours vs. primary tumours (c, d). Analyses were performed on 269 tumours with exome sequencing data (from the ICR1, ICR2, DFCI, and TCGA sample series) after excluding those samples with missing histology and/or missing tumour purity estimate (n = 20), and one sample with an excessively high TMB (DFCI_C13_T1) (n = 269, a, c). Analyses were also restricted to a subset of tumours comprising either only primary tumours (n = 239, b) or tumours from cases with platinum resistant disease (n = 64, d). Boxes show the median ± 25–75th percentiles, whiskers show 1.5× interquartile range below and above the 25th and 75th percentiles, respectively. p values are derived via two-sided multiple linear regression models adjusting for sample stage, histology, platinum response, dataset, and tumour purity.