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. 2020 May 4;11(5):314. doi: 10.1038/s41419-020-2503-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Neurons were exposed to AF568-tagged TauO (Red) from AD, PSP, or DLB for 1 h. Cells were immunolabeled with a presynaptic marker (Synapsin I, green) (a), a postsynaptic marker (PSD-95, green) (b), and a mature neuronal marker (βIII-tubulin, blue). Representative regions of interest are depicted in white rectangles with inserted high-magnification below. Scale bar is indicated. AD, PSP, or DLB TauO are located near the presynaptic marker. White arrows indicate AD, PSP, or DLB TauO co-localized with the postsynaptic marker. c Pearson’s correlation coefficient analysis of exogenous AD, PSP, and DLB TauO with pre- and postsynaptic markers over 1 h. Each treatment group was randomly imaged in five different regions of interest, and performed in triplicate. Image analyses were calculated by one-way ANOVA with Tukey’s multiple comparison test. Results showed as the value of mean ± SEM, ****p < 0.0001.