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. 2020 May 4;10:7478. doi: 10.1038/s41598-020-63441-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of the myelosuppression model for the absolute neutrophil counts (ANC) of the patients. (A) Prediction-corrected visual predictive check. Solid circles represent observed ANC, solid lines represent the median of the observed data, and dashed lines the 2.5 and 97.5 percentiles of the observations. Shaded areas are the 95% confidence intervals based on the simulated data (n = 1000) for the corresponding percentiles. (B) Percentage of patient in grade 1,2,3 and 4 neutropenia (grade 1: >1.5 ANC, grade 2: 1–1.5 ANC, grade 3: 0.5–1 ANC, grade 4: <0.5 ANC). Boxplots summarize the result of the 500 simulations and the red cross represents the real percentage values from the dataset.