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. 2020 May 4;6:33. doi: 10.1038/s41420-020-0267-2

Fig. 3. IL-33 deficiency relieved the disease severity of BPD.

Fig. 3

E14–15d pregnant dams (WT and IL-33 KO) were intraperitoneally injected with 75 µg/kg LPS, and newborn mice were exposed to 65% hyper-oxygen to establish BPD model. a–d Lung morphometry was analyzed by H&E staining of tissue samples from surviving pups at day 14 post birth. Scale bar, 200 μm. e IL-33 and fibronectin protein expression in pulmonary tissues at day 14 post birth. f Representative results of immunohistochemical analysis of fibronectin in pulmonary tissues at day 14 post birth. Scale bars, 100 μm. Three mice were included in the control and BPD group at each time point. All experiments were repeated at least three times.*P < 0.05, **P < 0.01, ***P < 0.001.