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. 2020 May 4;6:33. doi: 10.1038/s41420-020-0267-2

Fig. 4. Knockout of the IL-33 receptor ST2 improved BPD.

Fig. 4

E14–15d pregnant dams (WT and ST2 KO) were intraperitoneally injected with 75 µg/kg LPS, and newborn mice were exposed to 65% hyper-oxygen to establish BPD model. a–d Lung morphometry was analyzed by hematoxylin and eosin (H&E) staining of tissue samples from surviving pups at day 14 post birth. Scale bars = 200 μm. e Fibronectin protein expression in pulmonary tissues at day 14 post birth. f Representative results of immunohistochemical analysis of fibronectin in pulmonary tissues at day 14 post birth. Scale bar, 100 μm. Three mice were included in the control and BPD group at each time point. All experiments were repeated at least three times. *P < 0.05, **P < 0.01, ***P < 0.001.