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. 2020 May 4;11(5):307. doi: 10.1038/s41419-020-2512-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The mRNA levels (a), protein levels (b), and relative protein densities (c) of CXCR7 in ihMSCs incubated with indicated concentrations of VEGF for 18 h. *p < 0.05 compared with the control (untreated) group. The CXCR7 mRNA levels (d) and its cell surface levels (e) in ihMSCs pretreated with the neutralizing anti-PDGFRα or anti-PDGFRβ antibody followed by stimulation with VEGF (12 ng/ml) for 24 h. Data are means ± SD (n = 9). *p < 0.001 compared with the control (untreated) group. ^#p < 0.01 compared with IgG-treated groups. f, g Verification of PDGFRα and PDGFRβ knockdown by siRNAs. Data are means ± SD (n = 6). *p < 0.001 compared with scramble (Scr.) siRNA. The CXCR7 mRNA levels (h) and its cell surface levels (i) in ihMSCs transfected with or without scramble (Scr.), PDGFRα or PDGFRβ siRNAs for 24 h followed by stimulation with VEGF (12 ng/ml) for 24 h. Data are means ± SD (n = 9). *p < 0.0001 compared to the control (untreated) group. ^#p < 0.01 compared with scramble (Scr.) siRNA.