Table 2.

Occurrence of any seizure and of generalized tonic–clonic seizure (GTCS) in patients with and without application of intranasal midazolam (in-MDZ)

Time (h)	Index seizure with in-MDZ treatment			Index seizure without in-MDZ treatment			p value*
	No seizure recurrence (no. of patients)	Seizure recurrence (no. of patients)	Patients with GTCS	No seizure recurrence (no. of patients)	Seizure recurrence (no. of patients)	Patients with GTCS
1	160	11	0	146	25	3	< 0.001
2	143	28	1	121	50	6	< 0.001
3	134	37	2	110	61	8	< 0.001
4	126	45	3	91	80	11	0.002
5	115	56	5	82	89	14	0.080
6	104	67	8	75	96	16	0.621
9	90	81	10	64	107	19	0.254
12	80	91	10	52	119	21	0.007
24	50	121	18	24	147	25	< 0.001

*McNemar’s test