Skip to main content
. 2020 Apr 28;12:112. doi: 10.3389/fnagi.2020.00112

TABLE 1.

Clinical characteristics in Parkinson’s disease patients.

Normal control (n = 28) PD (n = 60)
Gender (male/female) 8/20 21/39 0.619
Age (years) 61.1 ± 4.9 62.8 ± 9.1 0.174
Cognitive impairment (%)* 0 78% <0.001
Disease duration (years) N.A. 1 (0.0, 3.0)
MMSE* 29.0 (28.0, 29.0) 26 (22.0, 27.0) <0.001
CDR* 0 0.50 (0.00, 0.50) <0.001
CDR sum of box* 0 0.50 (0.00, 2.00) <0.001
Modified Hoehn and Yahr scale, mean N.A. 2.00 (0.00, 2.50)
UPDRS I, mean N.A. 3.00 (2.00, 5.00)
UPDRS II, mean N.A. 9.00 (6.00, 12.00)
UPDRS III, mean N.A. 20.00 (16.00, 34.00)
UPDRS total, mean N.A. 32.00 (23.00, 48.00)
α-synuclein (pg/ml)* 0.06 (0.02, 0.08) 1.35 (0.88, 1.98) <0.001
Aβ1-40 (pg/ml)* 56.45 (48.78, 65.05) 35.73 (31.71, 41.83) 0.018
Aβ1-42 (pg/ml) 14.37 (13.42, 17.91) 18.05 (16.00, 21.60) 0.539
T-Tau (pg/ml)* 14.67 (11.02, 22.48) 31.87 (26.06, 3733) <0.001

Mean ± standard deviation or median (interquartile range). In clinical characteristics, gender was analyzed by using chi-square. Age, MMSE, CDR and CDR sum of box were analyzed by using the Mann–Whitney U test. PD = Parkinson’s disease; UPDRS = The Unified Parkinson’s Disease Rating Scale; MMSE = Mini-Mental State Examination; CDR = Clinical Dementia Rating; * = P < 0.05 vs. normal control.