TABLE 1.

Summary of conserved polarity regulators and their reported phospholipid-binding capacity.

Mammalian	Drosophila	C. elegans	Phospholipid-binding
Apical
PAR-3	Bazooka	PAR-3	PI(4,5)P2, PI(3,4,5)P3
PAR-6	PAR-6	PAR-6	–
PKCζ/ι	aPKC	PKC-3	–
Cdc42	Cdc42	Cdc42	PS
Rac1	Rac1	Rac-2	PA, PI(4,5)P2, PI(3,4,5)P3
Tiam1	–	–	PI(3,4)P2, PI(4,5)P2, PI(3,4,5)P3
PTEN	PTEN	DAF-18	PI(4,5)P2, (PS, PC)
Annexin-2	–	–	PI(4,5)P2
Crb1/2/3	Crb	Crb-1	–
Pals1	Stardust	Magu-2	–
PATJ	PATJ	Mpz-1	–
Basolateral
Llgl	Lgl	Lgl-1	PI(4)P, PI(4,5)P2
Dlg1	Dlg	Dlg-1	–
Scrb	Scrb	Let-413	–
MARK3	PAR-1	PAR-1	PS, PA, PI(4)P
LKB1	LKB1	PAR-4	PA