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. 2020 Apr 28;7:67. doi: 10.3389/fmolb.2020.00067

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Copyright © 2020 Azpeitia and Wagner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic description of the model and main concepts. (A) k_a and k_d correspond to the association and dissociation rate, respectively; k₁ and k₂ correspond to the mRNA and protein synthesis rate, respectively; d₁ and d₂ correspond to the mRNA and protein degradation rate, respectively. Relationships of both residence time and affinity with (B) the stability of the TF-DNA_bs complex, and (C) TF-DNA_bs binding probability. (D) Relationship of affinity and TF concentration with the level of induction.