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. 2020 Apr 28;7:67. doi: 10.3389/fmolb.2020.00067

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Copyright © 2020 Azpeitia and Wagner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Residence time and information. (A) Schematic explanation of the relationship between noise and acquired information. The panel shows hypothetical response protein distributions produced by two different stimuli at a high (right) and a low (left) level of gene expression noise. (B) Acquired information at different residence times as a function of the affinity (K_eq) between TF molecules and DNA. (C,D) Distributions of the number of expressed proteins N_P at three different TF concentrations (see color legend) with a long (C), and a short (D) residence time. In (C) and (D), K_eq = 10^–9M.