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. 2020 Apr 28;8:308. doi: 10.3389/fcell.2020.00308

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Copyright © 2020 Lupo, Piro, Torroni, Delfino, Trovato, Rusev, Fiore, Filippini, De Sanctis, Manfredi, Marengo, Lawlor, Martini, Tortora, Ugel, Corbo, Melisi and Carbone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Obesity accelerated the carcinogenesis and growth of both mP and mT pancreatic organoid models. Representative micrographs of pancreatic cysts of ob/ob, HFD and LFD mice bearing mP and mT organoid models. Hematoxylin & eosin staining, original magnifications: 100x and 200x, scale bar 100 μm; The H&E stained slides of the pancreatic tissue excised (A) at 21 days and (B) 35 days. Each lesion was reviewed by a pathologist and a score of progression assigned (normal stratification of ducts; to invasive carcinoma (C,D); (E) Representative images of peritoneal metastasis in the mT organoid bearing mice (groups: mT_LFD = 3; mT_HFD = 3; mT_ob/ob = 2); (F) Quantification of retro-peritoneal metastasis in the mT organoid bearing mice (groups: mT_LFD = 3; mT_HFD = 3; mT_ob/ob = 2). Data are shown as the percentage of mice with metastases in the indicated site. The picture reported the percentage of mice presenting with at least one metastasis in indicated organs.