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. 2020 Apr 28;8:308. doi: 10.3389/fcell.2020.00308

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Copyright © 2020 Lupo, Piro, Torroni, Delfino, Trovato, Rusev, Fiore, Filippini, De Sanctis, Manfredi, Marengo, Lawlor, Martini, Tortora, Ugel, Corbo, Melisi and Carbone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune and cytokine profiles of organoid-transplant model systems. Cytofluorimetric analysis for immune cells in (A) peripheral blood of mP and mT organoids model bearing-mice and (B) in the resected pancreata of mT organoids model bearing-mice. The data were shown as a percentage relative to the CD45⁺ cell population. Three independent experiments are shown; (C) Multiplex analysis of proinflammatory circulating factors. Plasma from peripheral blood was collected from each group of mice (n = 3) before and after (LFD n = 3, HFD n = 3, Ob/Ob n = 2) (35 days) mP and mT organoid injections. Concentrations of proinflammatory cytokines were analyzed using Luminex technology. Concentrations of cytokines (pg/mL) were calculated. The values for each cytokine (chemokine was reported as fold increase of each protein respect to expression value of mP LFD model as control. The mean values and standard deviation are shown. ***, p < 0.001; *, p < 0.05 by two-tailed unpaired Student’s t-tests.