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. 2020 Apr 28;8:308. doi: 10.3389/fcell.2020.00308

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Copyright © 2020 Lupo, Piro, Torroni, Delfino, Trovato, Rusev, Fiore, Filippini, De Sanctis, Manfredi, Marengo, Lawlor, Martini, Tortora, Ugel, Corbo, Melisi and Carbone.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proteomic analysis from DIO, GIO and LFD mP and mT tumor-bearing mice confirmed the increase of inflammation and carcinogenesis in obese mouse. Venn diagram of modulated proteins in mP (A) and mT (B) model systems. (C) Volcano plot showing differentially expressed proteins. The volcano plot showed the results of differentially expressed proteins systems based on fold change versus t-test probability from both mP and mT pancreatic organoids in obese mice rispect to lean mice. Each protein is represented as a dot and is mapped according to its fold change on the ordinate axis (y) and t-test p-value on the abscissa axis (x). (D) Survival analyses of pancreatic cancer patients dichotomized by high and low expression of some of differentially upregulated proteins in the serum of obese models rispect to lean mice. The overall survival data were obtained from https://dcc.icgc.org/releases/current/Projects/PACA-AU. Median survival was estimated with the Kaplan-Meier method and the difference was tested using the log-rank (Mantel-Cox) test.