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. 2020 Apr 28;10:165. doi: 10.3389/fcimb.2020.00165

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Copyright © 2020 Rajamanickam, Munisankar, Dolla and Babu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low BMI is associated with diminished circulating levels of HNP1-3, granulysin, HBD-2 and cathelicidin. (A) The plasma levels of HNP1-3, granulysin, HBD-2, and cathelicidin (LL37) were measured by ELISA in LTBI-LBMI (n = 44), LTBI-NBMI (n = 44), and HC (n = 44) individuals. The data are depicted as scatter plots and each circle represents a single person. (open circle–LTBI with LBMI and light gray–LTBI with NBMI and dark gray- LTBI with HBMI). P-values were calculated using the Kruskal Wallis test with Dunn's multiple comparison test. (B) Relationship between the levels of HNP1-3, granulysin, HBD-2, and cathelicidin (LL37) and BMI in LTBI individuals. The relationship between the systemic levels of HNP1-3 and granulysin, HBD-2 and cathelicidin (LL37) and BMI were examined in all LTBI (n = 88) individuals. p and r-values were determined by Spearman rank correlation at 95% confidence intervals.