FIGURE 5.

Sex-specific effect of caloric restriction on the time course of spontaneous Ca^{2 +} transients. Box-and-whisker plots illustrating the sex-specific effects of CR6 on the median (per cell) frequency (A), amplitude (B), T-half (C), and AUC (D) of spontaneous Ca^{2 +} transients [n = 10 cells (7 males), 18 cells (7 females) for control and n = 5 cells (3 males), 11 cells (5 females) for CR6 groups]. Statistical differences were determined using two-way ANOVA followed by the Bonferroni’s post hoc test (*p ≤ 0.05, **p < 0.01).