Table 2.
Correlation of characteristics with the ALBI and AAPR of 477 ICC patients treated with surgical resection in the derivation cohort.
| Characteristics | ALBI | AAPR | ||||
|---|---|---|---|---|---|---|
| Grade 1 (n = 387) | Grade 2 (n = 90) | P value | >0.348 (n = 293) | ≤0.348 (n = 184) | P-value | |
| Age [year, mean (SD)] | 57.1 (10.7) | 56.2 (10.9) | 0.958 | 56.9 (10.9) | 56.9 (10.4) | 0.998 |
| Male gender, n (%) | 175 (45.2) | 52 (57.8) | 0.032 | 143 (48.8) | 84 (45.7) | 0.511 |
| HBsAg [positive, n (%)] | 106 (27.5) | 33 (37.1) | 0.091 | 106 (36.6) | 33 (18.0) | <0.001 |
| Hepatolithiasis, n (%) | 61 (15.8) | 22 (24.4) | 0.061 | 40 (13.7) | 43 (23.4) | 0.006 |
| Child–Pugh score, n (%) | ||||||
| 5 | 348 (89.9) | 59 (65.5) | <0.001 | 265 (90.4) | 142 (77.2) | <0.001 |
| 6 | 39 (10.1) | 27 (30.0) | 27 (9.2) | 39 (21.2) | ||
| Ascites, n (%) | 36 (9.3%) | 11 (12.2) | 0.432 | 24 (8.2) | 23 (12.5) | 0.152 |
| ALB [g/L, mean (SD)] | 43.9 (2.9) | 36.6 (3.1) | <0.001 | 43.5 (3.5) | 41.2 (4.6) | <0.001 |
| TBIL [μmol/L, mean (SD)] | 13.6 (5.7) | 17.1 (15.4) | 0.001 | 13.8 (5.8) | 15.1 (11.6) | 0.102 |
| ALP [U/L, mean (SD)] | 128.1 (85.1) | 172.7 (123.8) | <0.001 | 88.7 (23.1) | 212.6 (114.8) | <0.001 |
| CA19-9 | ||||||
| <22, n (%) | 114 (30.2) | 23 (25.8) | 0.439 | 93 (32.4) | 44 (24.4) | 0.075 |
| ≥22, n (%) | 264 (69.8) | 66 (74.2) | 194 (67.6) | 136 (75.6) | ||
| Tumor size [cm, mean (SD)] | 5.8 (2.5) | 6.6 (3.3) | 0.014 | 5.5 (2.3) | 6.8 (3.2) | <0.001 |
| Solitary tumor, n (%) | 276 (71.3) | 61 (67.8) | 0.536 | 217 (74.1) | 120 (65.2) | 0.113 |
| Tumor differentiation | ||||||
| Well | 10 (2.6) | 2 (2.2) | 0.068 | 10 (3.4) | 2 (1.1) | 0.022 |
| Moderate | 302 (78.0) | 60 (66.7) | 219 (74.7) | 143 (77.7) | ||
| Poor | 55 (14.2) | 23 (25.6) | 54 (18.4) | 24 (13) | ||
| Macrovascular invasion, n (%) | 82 (21.2) | 24 (26.7) | 0.324 | 50 (17.1) | 56 (30.4) | 0.001 |
| Microvascular invasion, n (%) | 43 (11.1) | 8 (8.9) | 0.579 | 29 (9.9) | 22 (12.0) | 0.550 |
| Cirrhosis, n (%) | 102 (26.4) | 34 (37.8) | 0.038 | 90 (30.7) | 46 (25) | 0.211 |
| Overall survival, months, mean (95% CI) | 25.6 (23.5, 27.6) | 21.9 (16.9, 26.9) | 27.4 (24.9, 29.8) | 20.9 (18.1, 23.9) | ||
ALBI, albumin–bilirubin; AAPR, albumin-to-alkaline phosphatase ratio; ALB, albumin; TBIL, total bilirubin; ALP, alkaline phosphatase; CA19-9, carbohydrate antigen 19-9; IQR, interquartile range; SD, standard deviation; CI, confidence interval.