Table 1.
Clinical and genetic features of APA patients in in vitro study.
| Number | sex | Age | Duration of hypertension (months) | Duration of hypokalemia (months) | BPmax (mmHg) | Kmin (mmol/l) | Cr (umol/l) | PRA, ng/ml/h | PAC, ng/dl | ACTH (pg/ml) | UFC (μg) | Diameter of APA (mm) | Amino acid changes of KCNJ5 gene |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 52 | 120 | 24 | 180/100 | 2.9 | 64 | 0.02 | 15.45 | 7.8 | 48.15 | 20 | G151R |
| 2 | M | 44 | 36 | 36 | 220/140 | 2.0 | 131 | 0.01 | 34.00 | 49.5 | 35.28 | 13.4 | WT |
| 3 | M | 41 | 24 | 1 | NA | 2.5 | 70 | 0.01 | 18.17 | 21.7 | 100.32 | 19 | G151R |
| 4 | F | 37 | 1 | 1 | 180/120 | 3.2 | 55 | 0.04 | 19.38 | 19 | NA | 13 | L168R |
| 5 | M | 30 | 24 | 3 | 210/130 | 2.5 | 84 | a | a | 59.5 | 25.74 | 15 | L168R |
| 6 | M | 48 | 48 | 24 | NA | 1.6 | 105 | 0.01 | 23.46 | 60 | 64.39 | 25 | G151R |
| 7 | M | 34 | 48 | 6 | 180/120 | 2.6 | 91 | 0.01 | 15.09 | NA | NA | 19 | G151R |
| 8 | M | 53 | 60 | 1 | 180/110 | 1.7 | 118 | a | a | NA | NA | 18 | E145Q |
| 9 | M | 37 | 24 | 0.5 | 184/119 | 3.2 | 62 | 0.01 | 13.98 | 7.9 | 77.50 | 22 | G151R |
| 10 | M | 40 | 48 | 2 | NA | 2.3 | 73 | 0.01 | 17.21 | 39.4 | 156.03 | 20 | L168R |
| 11 | F | 57 | 204 | 2 | 180/110 | 1.4 | 85 | 0.01 | 18.25 | 14 | 41.60 | 14 | L168R |
| 12 | F | 31 | 120 | 0.25 | 250/140 | 2.6 | 78 | 0.01 | 24.1 | NA | NA | 18 | L168R |
| 13 | F | 42 | 72 | 6 | 220/110 | 65 | 0.43 | 13.69 | 8.3 | 17.42 | 14.3 | G151R | |
| 14 | F | 54 | 144 | 72 | 190/120 | 2.7 | 58 | 0.01 | 25.71 | 102 | 52.80 | 15 | G151R |
| 15 | F | 35 | 6 | 6 | NA | 56 | 0.01 | 31.00 | 37.7 | NA | 18 | E145Q | |
| 16 | F | 37 | 144 | 5 | 210/150 | 3.2 | 49 | 0.01 | 13.25 | 9.07 | 50.00 | NA | c.469-477delATCACAGAG |
| 17 | M | 64 | 72 | 24 | 180/110 | 1.9 | 80 | 0.09 | 13.97 | 46.3 | 68.89 | 13 | G151R |
| 18 | F | 32 | 5 | 2 | 207/127 | 3.1 | 54 | 0.04 | 16.60 | 27.3 | NA | 18 | L168R |
| 19 | M | 55 | 180 | 6 | 160/105 | 2.1 | 81 | 0.01 | 22.73 | 24.4 | 70.31 | 17 | G151R |
| 20 | M | 66 | 132 | 96 | 200/100 | 2.5 | 105 | 0.01 | 24.65 | 26.6 | 51.33 | 16 | L168R |
| 21 | F | 51 | 240 | 96 | 200/120 | 1.8 | 114 | 0.01 | 21.02 | 20 | 63.00 | 22 | L168R |
| 22 | M | 69 | 240 | 1 | 180/110 | 2.7 | 100 | 0.01 | 37.94 | 24.6 | 58.50 | 22 | G151R |
| 23 | M | 45 | 48 | 6 | 170/110 | 2.0 | 83 | 0.01 | 14.76 | NA | NA | 20 | L168R |
| 24 | M | 37 | 60 | 36 | 160/115 | 2.2 | 90 | 0.01 | 26.66 | 27.7 | 57.20 | 20 | G151R |
| mean ± SD | 45.5 ± 11.4 | 60*(33, 135) | 6* (1.8, 24) | 192 ± 22/119 ± 13 | 2.4 ± 0.5 | 81 ± 22 | 0.01* (0.01, 0.01) | 20.96 ± 6.94 | 25.6*(17.8, 41.1) | 57.20*(48.15, 68.89) | 17.9 ± 3.3 |
BP max, the maximum blood pressure; K min: the minimal potassium concentration; Cr, creatine; UFC: urine free cortisol; PRA, plasma renin activity; PAC, plasma aldosterone concentration; NA, not available;
*
Median (25%, 75%);
a
The values were detected in another hospital with a different method.