Table 1.
Cases of optic nerve lymphoma.
| Patients' number | References | Age/ sex | Diagnosis | Method of diagnosis | Classification | Initial complaint | Optic disc at present | Lumbar puncture | MRI | Treatment | VA outcome | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Enlargement | Enhancement | Intrinsic/ sheath | Location | |||||||||||
| 1 | (6) | 44/M | Hodgkin's disease | Chiasm and lymph node biopsy | PCNSL | Decreased VA and flashing lights (OU) | Pallor (OU) |
n/a | Yes | n/a | n/a | Optic chiasm | Radiotherapy, chemotherapy and corticosteroid | n/a (died) |
| 2 | (7) | 21/M | Hodgkin's disease | Lymph node biopsy | Systemic lymphoma | Decreased VA (OS) | Edema (OS) |
wnl | Yes | Marked | Intrinsic and sheath enhancement | Left intraorbital and intracanal optic nerve | Radiotherapy and corticosteroid | Improved |
| 3 | (8) | 42/F | NHL | Lymph node biopsy | Systemic lymphoma | Decreased VA (OD) VF defect (OS) |
Pallor (OU) |
High protein | Yes | n/a | n/a | Optic chiasm | Radiotherapy | Stable |
| 4 | (9) | 69/F | Small cleaved-cell lymphoma | Temporal artery biopsy and bone marrow biopsy | Systemic lymphoma | Decreased VA (OS) | Normal (OS) |
High protein | Yes | Marked | Intrinsic and sheath enhancement | Left intraorbital, intracanal optic nerve and anterior chiasm | Radiotherapy and corticosteroid | Improved |
| 5 | (10) | 74/F | B-cell NHL | Optic nerve biopsy | Systemic lymphoma | Transient decreased VA and VF defect (OS) |
Edema (OU) |
High protein | Yes | No | n/a | Optic nerve* | Radiotherapy | Improved |
| 6 | (11) | 87/F | B-cell NHL | Lymph node and bone marrow biopsy | Systemic lymphoma | Decreased VA (OU) | Edema (OU) |
n/a | Yes | Marked | Intrinsic and sheath enhancement | Bilateral intraorbital optic nerve | Corticosteroid and chlorambucil | Improved |
| 7 | (12) | 70/F | NHL | Bone marrow biopsy | Systemic lymphoma | Decreased VA (OU) | Mild edema (OU) | wnl | Yes | Yes | Intrinsic and sheath enhancement | Bilateral optic nerves* | Corticosteroid and chlorambucil | Improved |
| 8 | (2) | 66/F | B-cell lymphoma | Optic nerve and sheath biopsy | Optic nerve lymphoma | Decreased VA (OD) | Edema (OD) |
wnl | n/a | Yes | n/a | Right intraorbital and intracanal optic nerve* | Corticosteroid | Deteriorated |
| Radiotherapy and chemotherapy | Stable | |||||||||||||
| 9 | (13) | 49/M | Small B-cell lymphoma | Optic nerve and sheath biopsy | Systemic lymphoma | Decreased VA and VF defect (OS) | Edema (OS) |
n/a | Yes | Moderate | Intrinsic and sheath enhancement | Left intraorbital and intracanal optic nerve | Radiotherapy | Stable |
| 10 | (14) | 69/M | Small B-cell NHL | Optic nerve and sheath biopsy | Optic nerve lymphoma | Decreased VA (OU) | Edema (OS) |
n/a | Yes | n/a | n/a | Bilateral intraorbital optic nerve and chiasm | Radiotherapy | Stable |
| 11 | (15) | 39/M | T-cell NHL | Optic nerve biopsy | Systemic lymphoma | Decreased VA (OU) | Edema (OU) |
n/a | n/a | Mild | Intrinsic and sheath enhancement | Right optic nerve and chiasm* | Radiotherapy and chemotherapy | Transient improved |
| 12 | (3) | 72/M | Small B-cell NHL | Optic nerve biopsy | PCNSL | Decreased VA (OD) | Pallor (OD) |
n/a | Yes | Marked | Intrinsic enhancement | Optic chiasm, tract and lateral geniculate | Chemotherapy | n/a (died) |
| 13 | (16) | 44/M | B-cell NHL | Retroperitoneal mass biopsy |
Systemic lymphoma | Decreased VA (OS) | Mild edema (OS) | High protein and B-cell neoplasm | Yes | Mild | Intrinsic and soft tissue along the optic nerve enhancement | Intraorbital optic nerve | Corticosteroids radiotherapy and chemotherapy | Stable |
| 14 | (4) | 59/M | Large B-cell NHL | Optic nerve (optic tract) | Optic nerve lymphoma | VF defect (OU) | n/a | n/a | Yes | Marked | Intrinsic enhancement | Optic nerve, chiasm and tract | Chemotherapy | Mild improved |
| 15 | (17)# | 84/F | Large B-cell NHL | Optic nerve biopsy | Optic nerve lymphoma | Decreased VA (OU) | n/a | n/a | Yes | Marked | Intrinsic enhancement | Optic chiasm | Corticosteroids | n/a |
| 16 | (17)# | 67/M | Large B-cell NHL | Optic nerve biopsy | PCNSL | Decreased VA (OD) | Edema (OD) |
n/a | Yes | Marked | Intrinsic enhancement | Optic canal and chiasm | Corticosteroids | Transient improved |
| 17 | (5)$ | 65/F | B-cell NHL | Optic nerve sheath biopsy | Systemic lymphoma | Decreased VA (OD) | Edema (OD) |
n/a | Yes | Moderate | Sheath enhancement | Intraorbital optic nerve | Radiotherapy | NLP |
| 18 | (5)$ | 25/F | Burkitt lymphoma | Optic nerve and sheath biopsy | Systemic lymphoma | Decreased VA (OS) | Edema (OD) |
n/a | Yes | Marked | Intrinsic and soft tissue along the optic nerve enhancement | Left intraorbital optic nerve | Radiotherapy | n/a (died) |
| 19 | (18) | 67/M | NHL | Post-mortem of the optic nerve | Systemic lymphoma | Decreased VA (OU) | Edema (OU) |
wnl | Yes | Marked | Intrinsic and sheath enhancement | Right intraorbital optic nerve | Corticosteroids and intrathecal methotrexate | Improved |
| 20 | (19) | 68/F | B-cell NHL | Optic nerve biopsy | Optic nerve lymphoma | Decreased VA (OU) | n/a | n/a | Yes | Marked | Intrinsic enhancement | Bilateral optic nerve, chiasm and tract | Corticosteroids radiotherapy and chemotherapy | n/a |
| 21 | Case 1 | 55/M | Large B-cell NHL | Brain biopsy | PCNSL | Decreased VA (OU) | Mild edema (OD) and pallor (OS) | High protein | Yes | Marked | Intrinsic enhancement | Optic chiasm and tract | Corticosteroids | Improved |
| 22 | Case 2 | 67/F | Small B-cell NHL | Bone marrow biopsy | Systemic lymphoma | Decreased VA (OU) VF defect (OU) |
Edema (OU) | High protein | Yes | Moderate | Intrinsic and sheath enhancement | Bilateral intraorbital optic nerve | No | n/a |
M, male; F, female; NHL, non-Hodgkin lymphoma; OD, right eye; OS, left eye; OU, both eyes; VA, visual acuity; VF, visual field; NLP, no light perception; n/a, information not available; CBC, complete blood count; wnl, within normal limits.
*
MRI images were not provided.
#
Case 15 and 16 are different patients from the same study.
$
Case 17 and 18 are different patients from the same study.