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. 2020 Apr 28;11:763. doi: 10.3389/fimmu.2020.00763

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Copyright © 2020 Lin, Tai, Brož, Tang, Chen, Wu, Li and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of adenosine signaling upon AcMNPV and BmNPV infection. RT-qPCR analyses of AdoR expression in B. mori larvae (A) BmN cells (B) as well as in different immune organs (C) upon AcMNPV or BmNPV infection at 48 h postinfection (hpi). (D) Measurement of hemolymph adenosine levels of larvae injected with PBS (control), AcMNPV or BmNPV at 48 hpi. All values are shown as the mean ± SEM of three replicates for qPCR and four replicates for adenosine measurement. Significance was determined by one-way ANOVA with Tukey's HSD post-hoc analysis; different letters for the treatment group indicate significant differences at P < 0.05. MG, midgut; HE, hemocyte; FB, fat body.