Figure 5.

Inhibition of adenosine transport by dipyridamole (Dipy) treatment decreased the ATP level, resulting in an increase in AcMNPV replication in BmN cells and larvae. The ATP level was measured at 48 h postinfection (hpi) with Dipy treatment in BmN cells (A) and larvae (C); values were normalized to those in the non-infected control BmN cells and BmNPV-infected larvae, respectively. Virus titers were estimated at 48 hpi in BmN cells (B) and larvae (D); BmNPV treatment represented the positive control. All values are shown as the mean ± SEM of four replicates for ATP level and three replicates for virus titer measurements. Significance was determined by one-way ANOVA with Tukey's HSD post-hoc analysis; different letters for the treatment group indicate significant differences at P < 0.05.