Table 1.
Toxicities of different NPs observed in various cells.
| S. no. | NPs | Cell types/lines | Toxicity observed |
|---|---|---|---|
| 1 | SWCNTs | Human MSTO-211H cells | Toxicity was found to increase from well dispersed CNTs to |
| asbestos and then to agglomerated CNTs | |||
| 2 | THF/nano C60 | Human dermal fibroblasts, liver carcinoma cells, astrocytes | mROS, lipid peroxidation, cell death |
| RAW 264.7 macrophages | ROS generation | ||
| Human umbilical vein endothelial cells | G1 cell cycle block | ||
| Human lens epithelial cells | Intracellular peroxides, apoptosis (phototoxicity) | ||
| 3 | CdSe/ ZnSSSA | EL-4 cells | Cytotoxic |
| Vero, HeLa, and primary human hepatocytes | Cytotoxic, hepatocytes | ||
| 4 | Cu | Two humans pulmonary cell lines (A549 and THP-1) | Cytotoxic, pulmonary inflammation, collagen accumulation |
| 5 | ZnO | BEAS-2B and RAW 264.7 macrophages | Increased intracellular calcium, decreased mitochondrial membrane potential, interleukin 8 productin |
| Neuro-2A cell line | |||
| 6 | Ag | Murine macrophage cell line | Cytotoxic |
| Mouse spermatogonial stem cells | Mitochondrial damage, enhanced formation of autosomes and autolysosomes, downregulation tight junctions | ||
| 7 | (CeO2) | Human lung carcinoma (A549) | Cytotoxic through ROS generation and reduced glutathione |
| 8 | Au/CeO2 | Human hepatocyte (C3A), human colon adenocarcinoma (CaCo-2), primary trout hepatocytes | Cytotoxicity effects |
| 9 | SiO2 | Mouse spleen | Decreased proliferation in B-cell and T-cell, decreased interleukins (IL-12. IL-6) |