Figure 7.
The signaling pathway network by which PF resists H2O2-induced oxidative stress in melanocytes. PF may depended on the JNK/Nrf2/HO-1 pathway to reduce oxidative damage which was reflected in suppressing reactive oxygen species (ROS) accumulation and enhancing the productions of superoxide dismutase (SOD) and antioxidant enzymes catalase (CAT), therefore, PF inhibited cell apoptosis and promoted cell proliferation., Moreover, PF promoted dendrite extension probably by inhibiting the actin polymerization in stressed cells. In addition, JNK increased the Nrf2 expression in PF-pretreated PIG1, but inhibited the expression of Nrf2 in PF-pretreated PIG3V under oxidative stress. Pathway Builder Tool 2.0 was used to draw this picture.