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. 2020 Apr 28;7:64. doi: 10.3389/fcvm.2020.00064

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Copyright © 2020 Oishi and Manabe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunometabolic crosstalk at multiple levels. The crosstalk between immune and metabolic mechanisms operates at multiple levels in the body to maintain homeostasis. The intricate crosstalk also crucially contributes to the development of systemic, tissue, and cellular dysfunction and disease. One key pathological mechanism mediated by immunometabolic crosstalk is chronic inflammation. The interaction between immune and metabolic cells is exemplified here by interaction between a macrophage and an adipocyte (82).