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. 2020 Apr 28;11:751. doi: 10.3389/fimmu.2020.00751

Figure 1.

Figure 1

MR1-restricted T cells in cancer. Bacterial metabolite-reactive MAIT cells, within the tumor microenvironment, are skewed toward the production of Th17 cytokines, promoting tumor growth and metastasis. MR1T cells recognizing MR1-presented tumor-associated antigens (TAA), release a vast array of cytokines and kill tumor cells, thus supporting cancer immunity.