1. Adverse events.

Study	Events in EDTA arm	n in EDTA arm	Events in placebo arm	n in placebo arm
Guldager 1992 Combined events	111	80	74	79
Guldager 1992 Hypocalcaemic symptoms	6	80	2	79
Guldager 1992 Fatigue	12	80	11	79
Guldager 1992 Faintness	11	80	1	79
Guldager 1992 Gastrointestinal symptoms	11	80	7	79
Guldager 1992 Serum‐creatinine increase	7	80	9	79
Guldager 1992 Proteinuria	10	80	4	79
Guldager 1992 Phlebitis at infusion site	35	80	28	79
Guldager 1992 Pain at infusion site	9	80	5	79
Guldager 1992 Headache	7	80	7	79
Guldager 1992 Raynaud's Phenomenon	1	80	0	79
Guldager 1992 Metallic taste	1	80	0	79
Guldager 1992 Dermatitis	1	80	0	79
TACT 2013 Combined events	100	839	127	869

EDTA: ethylene diamine tetra‐acetic acid