Source	Search strategy	Hits retrieved
CENTRAL	#1 MESH DESCRIPTOR Cardiovascular Diseases EXPLODE ALL TREES 92399 #2 cardiovasc*:TI,AB,KY 49961 #3 coronary:TI,AB,KY 43789 #4 heart:TI,AB,KY 104388 #5 myocardial:TI,AB,KY 32708 #6 circulat*:TI,AB,KY 23247 #7 CAD:TI,AB,KY 3397 #8 MESH DESCRIPTOR Ischemia 1542 #9 (atherosclero* or arteriosclero* or PVD or PAOD or PAD ):TI,AB,KY 12285 #10 ((arter* or vascular or vein* or veno* or peripher*) near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ):TI,AB,KY 10672 #11 (peripheral near3 dis*):TI,AB,KY 4875 #12 (claudic* or IC):TI,AB,KY 4130 #13 (isch* or CLI):TI,AB,KY 32430 #14 arteriopathic:TI,AB,KY 7 #15 dysvascular*:TI,AB,KY 23 #16 (leg near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ):TI,AB,KY 130 #17 (limb near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ):TI,AB,KY 227 #18 ((lower near3 extrem*) near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ):TI,AB,KY 101 #19 ((iliac or femoral or popliteal or femoro* or fempop* or crural) near3(occlus* or reocclus* or re‐occlus* or steno*or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ):TI,AB,KY 1486 #20 MESH DESCRIPTOR Leg EXPLODE ALL TREES 2801 #21 ((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) near3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) ):TI,AB,KY 1731 #22 #1 OR #2 OR #3 OR #4 OR #5 OR #6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12 OR #13 OR #14 OR #15 OR #16 OR #17 OR #18 OR #19 OR #20 OR #21 230870 #23 MESH DESCRIPTOR Chelation Therapy EXPLODE ALL TREES 74 #24 MESH DESCRIPTOR Chelating Agents EXPLODE ALL TREES 2865 #25 ethylenediamine*:TI,AB,KY 245 #26 (ethylen* near2 diamine*):TI,AB,KY 50 #27 chelat*:TI,AB,KY 1291 #28 EDTA:TI,AB,KY 1033 #29 #23 OR #24 OR #25 OR #26 OR #27 OR #28 4412 #30 #22 AND #29 759 #31 01/01/2015 TO 14/08/2018:CD 465323 #32 #30 AND #31 283	15 August 2018: 283 6 August 2019: 113
Clinicaltrials.gov	Cardiovascular or coronary or heart or myocardial or Ischemia or atherosclerosis or arteriosclerosis | Chelation or Chelating or ethylenediamine or EDTA	15 August 2018: 0 6 August 2019: 0
ICTRP Search Portal	Cardiovascular or coronary or heart or myocardial or Ischemia or atherosclerosis or arteriosclerosis | Chelation or Chelating or ethylenediamine or EDTA	15 August 2018: 5 6 August 2019: 1
MEDLINE (Ovid MEDLINE® Epub Ahead of Print, In‐Process & Other Non‐Indexed Citations, Ovid MEDLINE® Daily and Ovid MEDLINE®) 1946 to present (2017, 2018 AND 2019 ONLY)	1 exp Cardiovascular Diseases/ 2209343 2 cardiovasc*.ti,ab. 381507 3 coronary.ti,ab. 363097 4 heart.ti,ab. 732184 5 myocardial.ti,ab. 309715 6 circulat*.ti,ab. 366774 7 CAD.ti,ab. 33317 8 ISCHEMIA/ 47686 9 (atherosclero* or arteriosclero* or PVD or PAOD or PAD).ti,ab. 172168 10 ((arter* or vascular or vein* or veno* or peripher*) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 143710 11 (peripheral adj3 dis*).ti,ab. 38010 12 (claudic* or IC).ti,ab. 62275 13 (isch* or CLI).ti,ab. 347926 14 arteriopathic.ti,ab. 162 15 dysvascular*.ti,ab. 217 16 (leg adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 710 17 (limb adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 1826 18 (lower adj3 extrem* adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 1484 19 ((iliac or femoral or popliteal or femoro* or fempop* or crural) adj3 (occlus* or reocclus* or re‐occlus* or steno*or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 7457 20 exp LEG/bs [Blood Supply] 25049 21 ((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 9734 22 or/1‐21 3277858 23 exp Chelation Therapy/ 1351 24 exp Chelating Agents/ 134882 25 ethylenediamine*.ti,ab. 11668 26 (ethylen* adj2 diamine*).ti,ab. 1458 27 chelat*.ti,ab. 60560 28 EDTA.ti,ab. 33715 29 or/23‐28 199079 30 22 and 29 13731 31 randomized controlled trial.pt. 466776 32 controlled clinical trial.pt. 92580 33 randomized.ab. 419286 34 placebo.ab. 191058 35 drug therapy.fs. 2039779 36 randomly.ab. 295554 37 trial.ab. 436605 38 groups.ab. 1824095 39 or/31‐38 4261870 40 exp animals/ not humans.sh. 4486684 41 39 not 40 3684348 42 30 and 41 2507 43 (2017* or 2018*).ed. 1591726 44 42 and 43 182 45 from 44 keep 1‐182 182	15 August 2018: 182 6 August 2019: 179
Embase 1974 to present (2017, 2018 AND 2019 ONLY)	1 exp cardiovascular disease/ 3430790 2 cardiovasc*.ti,ab. 523409 3 coronary.ti,ab. 483622 4 heart.ti,ab. 955801 5 myocardial.ti,ab. 408418 6 circulat*.ti,ab. 440655 7 CAD.ti,ab. 54144 8 ischemia/ 70891 9 (atherosclero* or arteriosclero* or PVD or PAOD or PAD).ti,ab. 221615 10 ((arter* or vascular or vein* or veno* or peripher*) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 185745 11 (peripheral adj3 dis*).ti,ab. 51387 12 (claudic* or IC).ti,ab. 60628 13 (isch* or CLI).ti,ab. 478891 14 arteriopathic.ti,ab. 179 15 dysvascular*.ti,ab. 229 16 (leg adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 938 17 (limb adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 2541 18 (lower adj3 extrem* adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 1937 19 ((iliac or femoral or popliteal or femoro* or fempop* or crural) adj3 (occlus* or reocclus* or re‐occlus* or steno*or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 10054 20 ((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 13112 21 or/1‐20 4409661 22 exp chelation therapy/ 3721 23 exp chelating agent/ 296819 24 ethylenediamine*.ti,ab. 11008 25 (ethylen* adj2 diamine*).ti,ab. 1655 26 chelat*.ti,ab. 65391 27 EDTA.ti,ab. 42205 28 or/22‐27 356023 29 21 and 28 44546 30 randomized controlled trial/ 485046 31 controlled clinical trial/ 453436 32 random$.ti,ab. 1254892 33 randomization/ 78352 34 intermethod comparison/ 224167 35 placebo.ti,ab. 263094 36 (compare or compared or comparison).ti. 439852 37 ((evaluated or evaluate or evaluating or assessed or assess) and (compare or compared or comparing or comparison)).ab. 1682909 38 (open adj label).ti,ab. 61736 39 ((double or single or doubly or singly) adj (blind or blinded or blindly)).ti,ab. 201044 40 double blind procedure/ 144948 41 parallel group$1.ti,ab. 20897 42 (crossover or cross over).ti,ab. 89779 43 ((assign$ or match or matched or allocation) adj5 (alternate or group$1 or intervention$1 or patient$1 or subject$1 or participant$1)).ti,ab. 271853 44 (assigned or allocated).ti,ab. 320163 45 (controlled adj7 (study or design or trial)).ti,ab. 281055 46 (volunteer or volunteers).ti,ab. 217627 47 trial.ti. 234687 48 or/30‐47 3865784 49 29 and 48 8652 50 (2017* or 2018*).em. 2792765 51 49 and 50 779 52 from 51 keep 1‐779 779	15 August 2018: 779 6 August 2019: 628
CINAHL (2017, 2018 AND 2019 ONLY)	S46 S44 AND S45 25 S45 EM 2017 OR EM 2018 410,156 S44 S29 AND S43 418 S43 S31 OR S32 OR S33 OR S34 OR S35 OR S36 OR S37 OR S38 OR S39 OR S40 OR S41 OR S42 344,690 S42 MH "Random Assignment" 39,170 S41 MH "Single‐Blind Studies" or MH "Double‐Blind Studies" or MH "Triple‐Blind Studies" 32,863 S40 MH "Crossover Design" 11,254 S39 MH "Factorial Design" 921 S38 MH "Placebos" 8,370 S37 MH "Clinical Trials" 93,027 S36 TX "multi‐centre study" OR "multi‐center study" OR "multicentre study" OR "multicenter study" OR "multi‐site study" 4,539 S35 TX crossover OR "cross‐over" 14,645 S34 AB placebo* 28,548 S33 TX random* 220,802 S32 TX trial* 252,333 S31 TX "latin square" 143 S30 S22 AND S29 466 S29 S23 OR S24 OR S25 OR S26 OR S27 OR S28 2,165 S28 TX EDTA 477 S27 TX chelat* 1,526 S26 TX ethylen* n2 diamine* 33 S25 TX ethylenediamine* 140 S24 (MH "Chelating Agents+") 1,104 S23 (MH "Chelation Therapy") 360 S22 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 463,910 S21 (femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) n3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) 1,094 S20 (MH "Leg/BS") 450 S19 TX (iliac or femoral or popliteal or femoro* or fempop* or crural) n3(occlus* or reocclus* or re‐occlus* or steno*or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) 878 S18 TX (lower n3 extrem*) n3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter* 119 S17 TX limb n3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) 277 S16 TX leg n3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) 126 S15 TX dysvascular* 172 S14 TX arteriopathic 10 S13 TX isch* or CLI 39,688 S12 TX claudic* or IC 5,894 S11 TX peripheral n3 dis* 9,264 S10 TX (arter* or vascular or vein* or veno* or peripher*) n3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*) 12,678 S9 TX atherosclero* or arteriosclero* or PVD or PAOD or PAD 26,494 S8 TX Ischemia 25,852 S7 TX CAD 4,214 S6 TX circulat* 47,409 S5 TX myocardial 51,509 S4 TX heart 177,885 S3 TX coronary 63,781 S2 TX cardiovasc* 126,171 S1 (MH "Cardiovascular Diseases+") 306,442	15 August 2018: 25 6 August 2019: 59
AMED (Allied and Complementary Medicine) 1985 to July 2019 (2017, 2018 AND 2019 ONLY)	1 cardiovasc*.ti,ab. 2619 2 coronary.ti,ab. 1294 3 heart.ti,ab. 5122 4 myocardial.ti,ab. 845 5 circulat*.ti,ab. 980 6 CAD.ti,ab. 155 7 ISCHEMIA/ 266 8 (atherosclero* or arteriosclero* or PVD or PAOD or PAD).ti,ab. 810 9 ((arter* or vascular or vein* or veno* or peripher*) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 461 10 (peripheral adj3 dis*).ti,ab. 439 11 (claudic* or IC).ti,ab. 1031 12 (isch* or CLI).ti,ab. 1687 13 arteriopathic.ti,ab. 1 14 dysvascular*.ti,ab. 58 15 (leg adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 21 16 (limb adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 32 17 (lower adj3 extrem* adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 25 18 ((iliac or femoral or popliteal or femoro* or fempop* or crural) adj3 (occlus* or reocclus* or re‐occlus* or steno*or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 52 19 ((femor* or iliac or popliteal or fempop* or crural or poplite* or infrapopliteal or inguinal or femdist* or inguinal or infrainquinal or tibial) adj3 (occlus* or reocclus* or re‐occlus* or steno* or restenos* or obstruct* or lesio* or block* or harden* or stiffen* or obliter*)).ti,ab. 110 20 or/1‐19 12379 21 exp Chelation therapy/ 40 22 exp Chelating agents/ 163 23 ethylenediamine*.ti,ab. 8 24 (ethylen* adj2 diamine*).ti,ab. 11 25 chelat*.ti,ab. 300 26 EDTA.ti,ab. 117 27 or/21‐26 364 28 20 and 27 70 29 exp CLINICAL TRIALS/ 3788 30 RANDOM ALLOCATION/ 314 31 DOUBLE BLIND METHOD/ 667 32 Clinical trial.pt. 1212 33 (clinic* adj trial*).tw. 5438 34 ((singl* or doubl* or trebl* or tripl*) adj (blind* or mask*)).tw. 2866 35 PLACEBOS/ 591 36 placebo*.tw. 3132 37 random*.tw. 17749 38 PROSPECTIVE STUDIES/ 1119 39 or/29‐38 22789 40 28 and 39 7 41 ("2017" or "2018").yr. 3424 42 40 and 41 0	15 August 2018: 0 6 August 2019: 0