Table 2. Rates of EOS per 1000 Live Births.
| Variable | All pathogens | GBS | Escherichia coli | |||
|---|---|---|---|---|---|---|
| No./total No. | Rate (95% CI)a | No./total No. | Rate (95% CI)a | No./total No. | Rate (95% CI)a | |
| All | 235/217 480 | 1.08 (0.95-1.23) | 71/217 480 | 0.33 (0.26-0.41) | 86/217 480 | 0.40 (0.32-0.49) |
| By birth weight, g | ||||||
| 401-1500 | 88/6322 | 13.92 (11.31-17.12) | 10/6322 | 1.58 (0.86-2.91) | 51/6322 | 8.07 (6.14-10.59) |
| 1501-2500 | 39/20 743 | 1.88 (1.38-2.57) | 7/20 743 | 0.34 (0.16-0.70) | 14/20 743 | 0.67 (0.40-1.13) |
| >2501 | 108/190 415 | 0.57 (0.47-0.68) | 54/190 415 | 0.28 (0.22-0.37) | 21/190 415 | 0.11 (0.07-0.17) |
| By GA, wk | ||||||
| 22-28 | 67/3628 | 18.47 (14.57-23.38) | 5/3628 | 1.38 (0.59-3.22) | 44/3628 | 12.13 (9.05-16.24) |
| 29-33 | 50/8056 | 6.21 (4.71-8.17) | 9/8056 | 1.12 (0.59-2.12) | 20/8056 | 2.48 (1.61-3.83) |
| 34-36 | 14/19 195 | 0.73 (0.43-1.22) | 3/19 195 | 0.16 (0.05-0.46) | 4/19 195 | 0.21 (0.08-0.54) |
| ≥37 | 104/185 970 | 0.56 (0.46-0.68) | 54/185 970 | 0.29 (0.22-0.38) | 18/185 970 | 0.10 (0.06-0.15) |
| By sex | ||||||
| Male | 127/111 543 | 1.14 (0.96-1.35) | 39/111 543 | 0.35 (0.26-0.48) | 50/111 543 | 0.45 (0.34-0.59) |
| Female | 108/105 977 | 1.02 (0.84-1.23) | 32/105 977 | 0.30 (0.21-0.43) | 36/105 977 | 0.34 (0.25-0.47) |
| Total (sites included in rates by race)b | 137/127 740 | 1.07 (0.91-1.27) | 37/127 740 | 0.29 (0.21-0.40) | 52/127 740 | 0.41 (0.31-0.53) |
| By race | ||||||
| Black | 47/40 250 | 1.17 (0.88-1.55) | 12/40 250 | 0.30 (0.17-0.52) | 19/40 250 | 0.47 (0.30-0.74) |
| White | 70/69 140 | 1.01 (0.80-1.28) | 20/69 140 | 0.29 (0.19-0.45) | 26/69 140 | 0.38 (0.26-0.55) |
| Other, unknown, or not reported | 20/18 089 | 1.11 (0.72-1.71) | 5/18 089 | 0.28 (0.12-0.65) | 7/18 089 | 0.39 (0.19-0.80) |
| Total (sites included in rates by ethnicity)c | 176/155 831 | 1.13 (0.97-1.31) | 56/155 831 | 0.36 (0.28-0.47) | 59/155 831 | 0.38 (0.29-0.49) |
| By ethnicity | ||||||
| Hispanic | 46/39 798 | 1.16 (0.87-1.54) | 15/39 798 | 0.38 (0.23-0.62) | 16/39 798 | 0.40 (0.25-0.65) |
| Non-Hispanic | 125/111 725 | 1.12 (0.94-1.33) | 40/111 725 | 0.36 (0.26-0.49) | 41/111 725 | 0.37 (0.27-0.50) |
| Unknown or not reported | 5/4393 | 1.14 (0.49-2.66) | 1/4393 | 0.23 (0.04-1.29) | 2/4393 | 0.46 (0.12-1.66) |
Abbreviations: EOS, early-onset sepsis; GA, gestational age; GBS, group B streptococcus.
Wilson 95% CIs are reported.
Data were excluded from calculations if the number of births was not reported by race (1 center) or if the number of births recorded as other, unknown, or not reported was more than 20% of the total live births reported (4 centers, 1 hospital at each of 2 additional centers) unless more than 20% of infants at the center were thought to have maternal race other than white or black as determined by center infants born 2015 to 2017 enrolled in the Neonatal Research Network high-risk registry (1 center that was 27% Asian and 1 center that was 29% American Indian/Alaska Native were not excluded).
Data were excluded from calculations if the number of births was not reported by ethnicity (2 centers, 1 hospital at each of 2 additional centers) or if the number of births recorded as unknown or not reported was more than 20% of the total live births reported (1 hospital at each of 2 centers).