Table 2.

Severity of cerulein-induced pancreatitis in AT1a−/− mice and WT controls

Mice	WT	AT1a−/−	WT	AT1a−/−	P‡
Cerulein	–	–	+	+
Abnormal architecture	0 ± 0	0 ± 0	2.0 ± 0.7	2.8 ± 0.5	0.29
Glandula atrophy	0 ± 0	0 ± 0	2.2 ± 0.8	2.8 ± 0.5	0.54
Psedotubular complexes	0 ± 0	0 ± 0	2.4 ± 0.6	3.0 ± 0	0.20
Necrosis	0 ± 0	0 ± 0	1.0 ± 0	1.25 ± 0.5	0.29
Total score of above	0 ± 0	0 ± 0	1.95 ± 0.8	2.44 ± 0.8
Acute inflammation*	0 ± 0	0 ± 0	1.4 ± 0.6	1.75 ± 0.5	0.20
Chronic inflammation†	0.5 ± 1.0	0 ± 0	2.4 ± 0.6	2.3 ± 0.5	0.85

Data are means ±SE (n = 4 mice per group).

^*For the acute inflammation, the content of acute inflammatory cells (neutrophils) was graded, and

^†for the chronic inflammation, the content of mononuclear cells was graded. For the description of the histopathology score see materials and methods.

^‡P values were calculated between cerulein-treated wild-type (WT) and AT1a−/− groups.