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. 2010 Apr 22;299(1):G70–G80. doi: 10.1152/ajpgi.00006.2010

Table 2.

Severity of cerulein-induced pancreatitis in AT1a−/− mice and WT controls

Mice WT AT1a−/− WT AT1a−/− P
Cerulein + +
Abnormal architecture 0 ± 0 0 ± 0 2.0 ± 0.7 2.8 ± 0.5 0.29
Glandula atrophy 0 ± 0 0 ± 0 2.2 ± 0.8 2.8 ± 0.5 0.54
Psedotubular complexes 0 ± 0 0 ± 0 2.4 ± 0.6 3.0 ± 0 0.20
Necrosis 0 ± 0 0 ± 0 1.0 ± 0 1.25 ± 0.5 0.29
Total score of above 0 ± 0 0 ± 0 1.95 ± 0.8 2.44 ± 0.8
Acute inflammation* 0 ± 0 0 ± 0 1.4 ± 0.6 1.75 ± 0.5 0.20
Chronic inflammation 0.5 ± 1.0 0 ± 0 2.4 ± 0.6 2.3 ± 0.5 0.85

Data are means ±SE (n = 4 mice per group).

*

For the acute inflammation, the content of acute inflammatory cells (neutrophils) was graded, and

for the chronic inflammation, the content of mononuclear cells was graded. For the description of the histopathology score see materials and methods.

P values were calculated between cerulein-treated wild-type (WT) and AT1a−/− groups.