Table 3.
Mice | WT | AT1b−/− | WT | AT1b−/− | ‡P |
---|---|---|---|---|---|
Cerulein | – | – | + | + | |
Abnormal architecture | 0 ± 0 | 0 ± 0 | 2.5 ± 0.6 | 2.0 ± 0.0 | 0.37 |
Glandula atrophy | 0 ± 0 | 0 ± 0 | 2.3 ± 0.5 | 2.8 ± 0.5 | 0.12 |
Psedotubular complexes | 0 ± 0 | 0 ± 0 | 1.5 ± 0.6 | 1.0 ± 0 | 0.37 |
Necrosis | 0 ± 0 | 0 ± 0 | 1.5 ± 0.6 | 1.0 ± 0.0 | 0.37 |
Total score of above | 0 ± 0 | 0 ± 0 | 1.94 ± 0.7 | 1.69 ± 0.8 | |
Acute inflammation* | 0 ± 0 | 0 ± 0 | 1.5 ± 1.0 | 1.0 ± 0.0 | 0.37 |
Chronic inflammation† | 0.25 ± 0.5 | 0 ± 0 | 2.3 ± 0.5 | 2.3 ± 0.5 | 0.37 |
Data are mean ±SE (n = 4 mice per group). For the acute inflammation
the content of acute inflammatory cells (neutrophils) was graded, and for the chronic inflammation
the content of mononuclear cells was graded. For the description of the histopathology score see materials and methods.
P values were calculated between cerulein-treated WT and AT1b−/− groups.