Table 3.

Severity of cerulein-induced pancreatitis in AT1b−/− mice and WT controls

Mice	WT	AT1b−/−	WT	AT1b−/−	‡P
Cerulein	–	–	+	+
Abnormal architecture	0 ± 0	0 ± 0	2.5 ± 0.6	2.0 ± 0.0	0.37
Glandula atrophy	0 ± 0	0 ± 0	2.3 ± 0.5	2.8 ± 0.5	0.12
Psedotubular complexes	0 ± 0	0 ± 0	1.5 ± 0.6	1.0 ± 0	0.37
Necrosis	0 ± 0	0 ± 0	1.5 ± 0.6	1.0 ± 0.0	0.37
Total score of above	0 ± 0	0 ± 0	1.94 ± 0.7	1.69 ± 0.8
Acute inflammation*	0 ± 0	0 ± 0	1.5 ± 1.0	1.0 ± 0.0	0.37
Chronic inflammation†	0.25 ± 0.5	0 ± 0	2.3 ± 0.5	2.3 ± 0.5	0.37

Data are mean ±SE (n = 4 mice per group). For the acute inflammation

^*the content of acute inflammatory cells (neutrophils) was graded, and for the chronic inflammation

^†the content of mononuclear cells was graded. For the description of the histopathology score see materials and methods.

^‡P values were calculated between cerulein-treated WT and AT1b−/− groups.