Table 5.

Evaluation of bias in individual studies

Author, Year Country	Research Question/Study Design	Possible Sources of Bias
Exercise
Radom-Aizik, 2010 United States	Does neutrophil miR expression change after brief exs?	quasiexperimental design
Baggish, 2011 United States	Does expression of circulating miRs change at rest and during exhaustive exs before and after aerobic training?	quasiexperimental design a priori approach to miR detection
Uhlemann, 2012 Germany	What are the effects of exs on miR-126 and endothelium?	quasiexperimental design a priori approach to miR detection
Aoi, 2013 Japan	Do circulating miRs change in response to acute and chronic exs?	quasiexperimental design a priori approach to miR detection
Banzet, 2013 Qatar	Are circulating muscle-specific miRs affected by exs and modality?	quasiexperimental design a priori approach to miR detection
Bye, 2013 Norway	Which miRs are associated with low vs. high V̇o2max?	cross-sectional design
Mooren, 2014 Germany	Are miRs associated with aerobic fitness performance capacity?	quasiexperimental design a priori approach to miR detection
Sawada, 2013 Japan	Are circulating miRs associated with resistance exs?	quasiexperimental design
Tonevitsky, 2013 Russia	How does miR change during exs?	quasiexperimental design
Zhou, 2013 China	Does physical activity influence metabolic syndrome risk by influencing miRs?	cross-sectional design subjective quantitation of exercise a priori approach to miR detection
Baggish, 2014 United States	Are plasma miRs uniquely modulated following sub-max-exs?	quasiexperimental design a priori approach to miR detection
Radom-Aizik, 2014 United States	Does brief exs alter monocyte miR expression?	quasiexperimental design
Diet
Milagro, 2013 Spain	Does miR expression characterize high (≥5% weight loss) vs. low responders to a diet intervention?	quasiexperimental design dietary intervention
Ortega, 2013 Spain	Are miRs associated with degree of obesity? Do miRs change after weight loss?	quasiexperimental design dietary intervention