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Aniline derivatives
| HBV replication inhibition | HBV RNaseH inhibiton | |||||
|---|---|---|---|---|---|---|
| Entry | Compound number | NR1R1 | EC50 (μM) | CC50 (μM) | SI | IC50 (μM) |
| 1 | 389 |  |
0.43 ± 0.23 | 21.2 ± 9.5 | 49.3 | 200 ± 190 |
| 2 | 711 |  |
0.75 ± 0.35 | 4.6 ± 0.8 | 6.1 | NA |
| 3 | 836 |  |
3.32 ± 0.67 | 5.4 ± 3.5 | 1.7 | 78.9 ± 49 |
| 4 | 799 |  |
3.25 ± 0.78 | 5.3 ± 3.1 | 1.6 | 78.5 ± 60 |
| 5 | 798 |  |
3.47 ± 0.49 | 3.3 ± 1.8 | 0.9 | 58.3 ± 49 |
| 6 | 835 |  |
5.07 ± 2.45 | 10.3 ± 5.2 | 2 | 86.0 ± 42 |
| 7 | 834 |  |
5.30 ± 0.10 | 16.4 ± 11.2 | 3.1 | 83.5 ± 69 |
| 8 | 837 |  |
6.0 ± 1.98 | 8.7 ± 3.4 | 1.5 | 119 ± 89 |
