Skip to main content
. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Antiviral Res. 2020 Mar 23;177:104777. doi: 10.1016/j.antiviral.2020.104777

Table 4.

Amino acid derivatives

HBV replication inhibition HBV RNaseH inhibiton
Entry Compound number R1 EC50 (μM) CC50 (μM) SI IC50 (μM)
1 797 graphic file with name nihms-1581389-t0040.jpg 0.91 ± 0.27 13.9 ± 13.3 15.3 52.3 ± 8.2
2 793 graphic file with name nihms-1581389-t0041.jpg 1.05 ± 0.38 18.3 ± 9.8 17.4 110 ± 10.5
3 796 graphic file with name nihms-1581389-t0042.jpg 1.10 ± 0.15 36.0 ± 24.1 32.7 25.4 ± 26.3
4 870 graphic file with name nihms-1581389-t0043.jpg 4.2 ± 0.71 9.1 ± 2.7 2.2 76.7 ± 94.4
5 867 graphic file with name nihms-1581389-t0044.jpg 5.25 ± 0.78 5.2 ± 1.3 1 567 ± 474
6 794 graphic file with name nihms-1581389-t0045.jpg 7.02 ± 4.74 14.7 ± 9.6 2.1 36.7 ± 14.6
7 869 graphic file with name nihms-1581389-t0046.jpg 13.6 ± 0.57 14.6 ± 3.4 1.1 769 ± 462
8 795 graphic file with name nihms-1581389-t0047.jpg 41.2 ± 39.7 12.7 ± 5.5 0.3 31.3 ± 1.4
9 868 graphic file with name nihms-1581389-t0048.jpg 54.5 ± 4.95 100 ± 0 1.8 40.7 ± 25.4