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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Antiviral Res. 2020 Mar 23;177:104777. doi: 10.1016/j.antiviral.2020.104777

Table 5.

Miscellaneous amide derivatives

HBV replication inhibition HBV RNaseH inhibiton
Entry Compound number NR1R2 EC50 (μM) CC50 (μM) SI IC50 (μM)
1 808 graphic file with name nihms-1581389-t0049.jpg 0.48 ± 0.17 14.9 ± 8.6 31.2 24.9 ± 5.5
2 707 graphic file with name nihms-1581389-t0050.jpg 0.54 ± 0.01 19.4 ± 8.4 35.9 NA
3 384 graphic file with name nihms-1581389-t0051.jpg 0.66 ± 0.67 17.6 ± 8.9 26.6 48.0 ± 31.8
4 712 graphic file with name nihms-1581389-t0052.jpg 0.77 ± 0.49 6.4 ± 0.8 8.3 47.5 ± 7.9
5 810 graphic file with name nihms-1581389-t0053.jpg 0.99 ± 0.52 10.9 ± 11.2 11 41.6 ± 9.3
6 1018 graphic file with name nihms-1581389-t0054.jpg 2.3 ± 0.28 41.2 ± 33.4 17.9 71.0 ± 21.6
7 805 graphic file with name nihms-1581389-t0055.jpg 2.45 ± 0.59 19.5 ± 10.8 8 78.7 ± 46.0
8 1039 graphic file with name nihms-1581389-t0056.jpg 3.35 ± 2.05 8.7 ± 2.8 2.6 33.9 ± 2.8
9 710 graphic file with name nihms-1581389-t0057.jpg 4.17 ± 4.04 4.5 ± 3.0 1.1 65.7 ± 18.1
10 709 graphic file with name nihms-1581389-t0058.jpg 4.23 ± 6.52 19.5 ± 6.7 4.6 81.0 ± 28.7
11 801 graphic file with name nihms-1581389-t0059.jpg 4.9 ± 1.67 61.1 ± 22.8 12.5 603 ± 354
12 874 graphic file with name nihms-1581389-t0060.jpg 5.75 ± 1.20 17.7 ± 6.7 3.1 597 ± 124
13 708 graphic file with name nihms-1581389-t0061.jpg 6.5 ± 5.24 22.6 ± 12.8 3.4 58.7 ± 15.5