6. Treatment‐related serious adverse events.
| Study | Intervention | Comparators | P value1 | ||||||
| Description | A/R | Type | Events | Description | A/R | Type | Events | ||
| Schiener 2007 | Salt bath + UVB | 284/310 | n.a. | 0 | UVB only | 252/301 | n.a. | 0 | 1.0 |
| Tap water + UVB | 266/301 | 1 x photodermatitis; 1 x exacerbation as guttate psoriasis; 1 alcohol problem |
3 | 0.1125 | |||||
| Psoralen bath + UVA | 297/321 | 2 x photodermatitis; 1 x malignant melanoma2 |
3 | 0.2491 |
1: Estimated by review authors using Easy Fisher Exact Test Calculator (Social Science Statistics 2018); statistically signifiant P values (P < 0.05) in bold font.
2: Schiener 2007 provided detailed information on the malignant melanoma case: "A malignant melanoma was diagnosed after the eighth irradiation. Queries at the trial site disclosed that an 'atypical nevus' had already been detected by a dermatologist 17 months before study enrollment. Furthermore, it is very unlikely that the tumor had progressed during the short period of 2 weeks." Though, a relationship between study intervention and event was judged as possible, we did not separately include the case as a secondary malignancy.
A/R: number of analysed/randomised people; n.a.: not applicable; UVA: artificial ultraviolet A light; UVB: artificial ultraviolet B light