Table 2.
Process and Pathway Enrichment Among Candidate Genes
| PANTHER GO-Slim Biological Process | Gene Content | Input | Expected | Fold Enrichment | P-value | FDR |
|---|---|---|---|---|---|---|
| activation of adenylate cyclase activity (GO:0007190) | 32 | 3* | 0.07 | 46.09 | 4.69 × 10 − 5 | 0.0353 |
| adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) | 32 | 3* | 0.07 | 46.09 | 4.69 × 10 −5 | 0.0235 |
| cAMP-mediated signaling (GO:0019933) | 41 | 3* | 0.08 | 35.98 | 9.38 × 10 −5 | 0.0282 |
| regulation of cAMP-mediated signaling (GO:0043949) | 41 | 3* | 0.08 | 35.98 | 9.38 × 10 −5 | 0.0235 |
| regulation of adenylate cyclase activity (GO:0045761) | 42 | 3* | 0.09 | 35.12 | 1.00 × 10 −4 | 0.0216 |
| regulation of lyase activity (GO:0051339) | 43 | 3* | 0.09 | 34.3 | 1.07 × 10 −4 | 0.0201 |
| cyclic-nucleotide-mediated signaling (GO:0019935) | 50 | 3* | 0.1 | 29.5 | 1.64 × 10 −4 | 0.0274 |
| regulation of biological process (GO:0050789) | 1359 | 11 | 2.76 | 3.98 | 3.87 × 10 −5 | 0.0582 |
| biological regulation (GO:0065007) | 1492 | 11 | 3.03 | 3.62 | 9.15 × 10 −5 | 0.0343 |
| PANTHER Pathways | Gene Content | Input | Expected | Fold Enrichment | P-value | FDR |
| PDGF signaling pathway (P00047) | 47 | 3 | 0.1 | 31.38 | 1.38 × 10−4 | 0.0213 |
| Endothelin signaling pathway (P00019) | 74 | 3* | 0.15 | 19.93 | 0.0495 | 0.0256 |
Enrichment analysis for the 29 genes associated with peroxide resistance. Gene Content is the number of genes in the respective process/pathway in the Drosophila genome (n = 13,767 genes in the GO database). Input is the number of resistance-associated genes in each process/pathway, and Expected is the number expected under the null hypothesis. Asterisks (*) indicate categories enriched due to the adenylyl cyclase X gene cluster