Table 5.
Clinico-pathological features of primary ovarian lesion of combined dataset: case dataset vs control dataset
| Clinico-histopathological features |
Case Dataset n = 40 (%) |
Control Dataset n = 40 (%) |
pValue |
|---|---|---|---|
| Age, median (years) [range] | 57 [39–76] | 63.5 [36–78] | 0.960 |
| Histological type | |||
| Serous | 34 (85) | 40 (100) | 0.262 |
| Clear cell | 2 (5) | ||
| Endometrioid | 1 (2.5) | ||
| Mucinous | 1 (2.5) | ||
| Squamous | 1 (2.5) | ||
| Undifferentiated | 1 (2.5) | ||
| Histological grade | |||
| G3 | 40 (100) | 40 (100) | 1 |
| FIGO stage | |||
| II | 4 (10) | 4 (10) | 1 |
| III | 25 (62.5) | 25 (62.5) | |
| IV | 11 (27.5) | 11 (27.5) | |
| Type of surgery | |||
| Upfront | 31 (77.5) | 18 (45) | 0.003 |
| Neoadjuvant CT + IDS | 9 (22.5) | 22 (55) | |
| Macroscopic residual tumor | |||
| Present | 17 (42.5) | 19 (47.5) | 0.611 |
| Absent | 14 (35) | 20 (50) | |
| Not available | 9 (22.5) | 1 (2.5) | |
| First-line chemotherapy | |||
| Platinum-based | 40 (100) | 40 (100) | 1 |
| Relapse | |||
| Present | 40 (100) | 30 (75) | 0.001 |
| Absent | 10 (25) | ||
| First site of relapse | |||
| CNS | 21 (52.5) | < 0.001 | |
| Lymph nodes and / or peritoneum | 14 (35) | 28 (93.3)a | |
| Other | 5 (12.5) | 2 (6.7)a | |
| Patient’s status | |||
| Alive | 10 (25) | 21 (52.5) | 0.015 |
| Dead | 29 (72.5) | 19 (47.5) | |
| Not available | 1 (2.5) | ||
| PFS, median (months) [range] | 18 [0–62] | 17.5 [5–73] | |
| OS, median (months) [range] | 47.5 [4–173] | 40 [6–101] | |
IDS Interval Debulking Surgery, CT Chemotherapy, CNS Central Nervous System, PFS Progression Free Survival, OS Overall Survival
aDisease progression did not occur for 10 patients